Several hypotheses have been proposed as follows i increased LH receptor sensitivity due to higher cumulative exposure to estradiol in conjunction with FSH; 3, 10 ii incomplete pituitary suppression by GnRH may result in some LH secretion sufficient to stimulate granulosa cells to produce progesterone despite not being enough to trigger ovulation; 11 iii the disruption of certain signaling pathways in the oocyte granulosa cell regulatory loop <a href=
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