I do think it is likely that we re going to have less emphasis on all these things, because I think the fact that we re going to see very few of these large adjuvant therapy trials in the future, the notion that we re going to be able to test these interventions in thousands of women is not going to be realistic going forward, and so I think that part of what this implies is that we have to really be thinking about new clinical trial designs, trying to identify important biomarkers, important biological targets, identifying agents that might affect patients who have those targets, and we would hope in that way that we would be able to refine our clinical trial designs and be able to trim them down to make them more feasible in the current era <a href=
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