The ecDHFR destabilising domain ecDDD is an unfolded, structurally unstable domain derived from the Escherichia coli dihydrofolate reductase DHFR gene, which was evolved for enhanced instability by introduction of two additional missense mutations R12Y Y110I, which when fused to proteins of interest similarly targets the fusion protein for rapid proteasomal degradation 12 <a href=
http://levitrax.pics>levitra professional overnight delivery</a> In contrast, while MIB2 expression shows an opposite trend and is elevated in TNBC relative to ER cancers, we did not find differences in the expression of MAPK14 p38 or MAPKAP2 MK2 between TCGA ER and TNBC samples Supplementary Fig